Structure of PDB 2rjp Chain A

Receptor sequence
>2rjpA (length=291) Species: 9606 (Homo sapiens) [Search protein sequence]
ASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVS
LVVTRLVILEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFT
RQDLCGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHQLGHVF
NMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLD
NGYGHCLLDKPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPC
AALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLH
3D structure
PDB2rjp Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.82: ADAMTS-4 endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H361 H365 H371 H144 H148 H154
BS02 CA A D320 L321 C327 T329 E349 D103 L104 C110 T112 E132
BS03 CA A E221 D304 D311 C423 D426 E8 D87 D94 C206 D209
BS04 CA A E221 D304 D426 E8 D87 D209
BS05 886 A T329 L330 G331 M332 F357 H361 Q362 H365 H371 V390 P393 V394 M395 V398 P403 T112 L113 G114 M115 F140 H144 Q145 H148 H154 V173 P176 V177 M178 V181 P186 PDBbind-CN: -logKd/Ki=7.00,IC50=0.1uM
BindingDB: IC50=100nM
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2rjp, PDBe:2rjp, PDBj:2rjp
PDBsum2rjp
PubMed18042673
UniProtO75173|ATS4_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 4 (Gene Name=ADAMTS4)

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