Structure of PDB 2rhc Chain A

Receptor sequence
>2rhcA (length=257) Species: 100226 (Streptomyces coelicolor A3(2)) [Search protein sequence]
DSEVALVTGATSGIGLEIARRLGKEGLRVFVCARGEEGLRTTLKELREAG
VEADGRTCDVRSVPEIEALVAAVVERYGPVDVLVNNAGRPGGGATAELAD
ELWLDVVETNLTGVFRVTKQVLKAGGMLERGTGRIVNIASTGGKQGVVHA
APYSASKHGVVGFTKALGLELARTGITVNAVCPGFVETPMAASVREHYSD
IWEVSTEEAFDRITARVPIGRYVQPSEVAEMVAYLIGPGAAAVTAQALNV
CGGLGNY
3D structure
PDB2rhc Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G17 N114 S144 Y157 K161 Y202
Catalytic site (residue number reindexed from 1) G13 N110 S140 Y153 K157 Y198
Enzyme Commision number 1.3.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G13 T15 S16 I18 A37 R38 G39 C62 D63 V64 N90 G92 S144 Y157 K161 G188 V190 T192 G9 T11 S12 I14 A33 R34 G35 C58 D59 V60 N86 G88 S140 Y153 K157 G184 V186 T188
BS02 EMO A T145 V151 Y157 F189 T141 V147 Y153 F185
Gene Ontology
Molecular Function
GO:0016491 oxidoreductase activity
Biological Process
GO:0008202 steroid metabolic process
GO:0017000 antibiotic biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2rhc, PDBe:2rhc, PDBj:2rhc
PDBsum2rhc
PubMed18205400
UniProtP16544|ACT3_STRCO Putative ketoacyl reductase (Gene Name=actIII)

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