Structure of PDB 2rgr Chain A

Receptor sequence
>2rgrA (length=721) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
RKSRITNYPKLEDANKAGTKEGYKCTLVLTEGDSALSLAVAGLAVVGRDY
YGCYPLRGKMLNVREASADQILKNAEIQAIKKIMGLQHRKKYEDTKSLRY
GHLMIMTDQDHDGSHIKGLIINFLESSFLGLLDIQGFLLEFITPIIKVSI
TKPTKNTIAFYNMPDYEKWREEESHKFTWKQKYYKGLGTSLAQEVREYFS
NLDRHLKIFHSLQGNDKDYIDLAFSKKKADDRKEWLRQYEPGTVLDPTLK
EIPISDFINKELILFSLADNIRSIPNVLDGFKPGQRKVLYGCFKKNLKSE
LKVAQLAPYVSECTAYHHGEQSLAQTIIGLAQNFVGSNNIYLLLPNGAFG
TRATGGKDAAAARYIYTELNKLTRKIFHPADDPLYKYIQEDEKTVEPEWY
LPILPMILVNGAEGIGTGWSTYIPPFNPLEIIKNIRHLMNDEELEQMHPW
FRGWTGTIEEIEPLRYRMYGRIEQIGDNVLEITELPARTWTSTIKEYLLL
GLSGNDKIKPWIKDMEEQHDDNIKFIITLSPEEMAKTRKIGFYERFKLIS
PISLMNMVAFDPHGKIKKYNSVNEILSEFYYVRLEYYQKRKDHMSERLQW
EVEKYSFQVKFIKMIIEKELTVTNKPRNAIIQELENLGFPRFNKEGKPYY
GSLYGTYEYLLGMRIWSLTKERYQKLLKQKQEKETELENLLKLSAKDIWN
TDLKAFEVGYQEFLQRDAEAR
3D structure
PDB2rgr Structural basis for gate-DNA recognition and bending by type IIA topoisomerases.
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A E449 K477 D530 R690 K700 H736 I833 E31 K59 D112 R272 K282 H318 I415
BS02 dna A R475 K477 L479 N480 H533 A647 R650 K651 I833 G834 T835 G836 W837 S838 K965 R57 K59 L61 N62 H115 A229 R232 K233 I415 G416 T417 G418 W419 S420 K547
BS03 MG A D526 D528 D108 D110
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change

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Molecular Function
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Biological Process
External links
PDB RCSB:2rgr, PDBe:2rgr, PDBj:2rgr
PDBsum2rgr
PubMed18097402
UniProtP06786|TOP2_YEAST DNA topoisomerase 2 (Gene Name=TOP2)

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