Structure of PDB 2rfs Chain A

Receptor sequence
>2rfsA (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
QHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLKIHCAVKSLNIGEVSQFLT
EGIIMKDFSHPNVLSLLGICLSPLVVLPYMKHGDLRNFIRNETHNPTVKD
LIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMY
DKEYYSVHTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAP
PYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSE
LVSRISAIFSTFIG
3D structure
PDB2rfs c-Met inhibitors with novel binding mode show activity against several hereditary papillary renal cell carcinoma-related mutations.
ChainA
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1204 A1206 R1208 N1209 D1222 A1243
Catalytic site (residue number reindexed from 1) D124 A126 R128 N129 D142 A161
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AM8 A I1084 G1085 L1140 L1157 P1158 Y1159 M1160 G1163 M1211 A1221 D1222 Y1230 I18 G19 L64 L77 P78 Y79 M80 G83 M131 A141 D142 Y150
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2rfs, PDBe:2rfs, PDBj:2rfs
PDBsum2rfs
PubMed18055465
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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