Structure of PDB 2rfe Chain A

Receptor sequence
>2rfeA (length=286) Species: 9606 (Homo sapiens) [Search protein sequence]
MALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREA
TSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLD
YVREHKDNIGSQYLLNWCVQIAEGMNYLEDRRLVHRDLAARNVLVKTPQH
VKITDFGLAKLLGAEEKVPIKWMALESILHRIYTHQSDVWSYGVTVWELM
TFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSR
PKFRELIIEFSKMARDPQRYLVIQGPTDSNFYRALM
3D structure
PDB2rfe Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface.
ChainA
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D813 A815 R817 N818 D831
Catalytic site (residue number reindexed from 1) D137 A139 R141 N142 D155
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A W881 E904 G906 E907 R908 P910 Q911 P913 C915 T916 I917 Y920 V924 M928 I929 W197 E220 G222 E223 R224 P226 Q227 P229 C231 T232 I233 Y236 V240 M244 I245
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2rfe, PDBe:2rfe, PDBj:2rfe
PDBsum2rfe
PubMed18046415
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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