Structure of PDB 2rew Chain A

Receptor sequence
>2rewA (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
ETADLKSLAKRIYEAYLKNFNMNKVKARVILSGPPFVIHDMETLCMAEKT
LQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYG
VYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFA
MKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHL
QSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQE
IYRDM
3D structure
PDB2rew Discovery of Azetidinone Acids as Conformationally-Constrained Dual (alpha/gamma) PPAR Activators
ChainA
Resolution2.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CPQ A K208 H411 K10 H199
BS02 REW A F273 C275 C276 Q277 S280 Y314 M330 V332 H440 Y464 F61 C63 C64 Q65 S68 Y102 M118 V120 H228 Y252 BindingDB: IC50=360nM,EC50=70nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2rew, PDBe:2rew, PDBj:2rew
PDBsum2rew
PubMed
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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