Structure of PDB 2rdt Chain A

Receptor sequence
>2rdtA (length=335) Species: 9606 (Homo sapiens) [Search protein sequence]
SMLPRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKL
YPRMLRNVAETDLSTSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQ
SLGTGMMLSSWATSSIEEVAEAGPEALRWLQLYIYKDREVTKKLVRQAEK
MGYKAIFVTVDTPYLGNRLDDVRNRFLAAYVAKAIDPSISWEDIKWLRRL
TSLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEI
VEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIVWGLAFQGEKG
VQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKN
3D structure
PDB2rdt Active Site and Loop 4 Movements within Human Glycolate Oxidase: Implications for Substrate Specificity and Drug Design.
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S108 Y132 T158 D160 K236 H260
Catalytic site (residue number reindexed from 1) S109 Y133 T159 D161 K208 H232
Enzyme Commision number 1.1.3.15: (S)-2-hydroxy-acid oxidase.
1.2.3.5: glyoxylate oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FMN A Y26 Y27 A79 T80 A81 S108 Q130 Y132 T158 K236 H260 G261 R263 D291 G292 G293 R295 G314 R315 Y27 Y28 A80 T81 A82 S109 Q131 Y133 T159 K208 H232 G233 R235 D263 G264 G265 R267 G286 R287
BS02 2RD A Y26 M82 W110 Y132 R167 H260 R263 Y27 M83 W111 Y133 R168 H232 R235 MOAD: Ki~15nM
BindingDB: Ki=15nM
Gene Ontology
Molecular Function
GO:0003973 (S)-2-hydroxy-acid oxidase activity
GO:0010181 FMN binding
GO:0016491 oxidoreductase activity
GO:0047969 glyoxylate oxidase activity
Biological Process
GO:0001561 fatty acid alpha-oxidation
GO:0006545 glycine biosynthetic process
GO:0006979 response to oxidative stress
GO:0008652 amino acid biosynthetic process
GO:0046296 glycolate catabolic process
Cellular Component
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix
GO:0005829 cytosol
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2rdt, PDBe:2rdt, PDBj:2rdt
PDBsum2rdt
PubMed18215067
UniProtQ9UJM8|HAOX1_HUMAN 2-Hydroxyacid oxidase 1 (Gene Name=HAO1)

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