Structure of PDB 2rdl Chain A

Receptor sequence
>2rdlA (length=226) Species: 10036 (Mesocricetus auratus) [Search protein sequence]
IIGGTECRPHARPYMAYLEIVTPENHLSACSGFLIRRNFVMTAAHCAGRS
ITVLLGAHNKKVKEDTWQKLEVEKQFPHPKYDDRLVLNDIMLLKLKEKAN
LTLGVGTLPISAKSNSIPPGRVCRAVGWGRTNVNEPPSDTLQEVKMRILD
PQACKHFEDFHQEPQLCVGNPKKIRNVYKGDSGGPLLCAGIAQGIASYVL
RNAKPPSVFTRISHYRPWINKILREN
3D structure
PDB2rdl Structural basis for elastolytic substrate specificity in rodent alpha-chymases.
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 G193 S195 G196
Catalytic site (residue number reindexed from 1) H45 D89 G180 S182 G183
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A H57 Y191 S195 S214 Y215 V216 R218 N219 H45 Y178 S182 S197 Y198 V199 R201 N202
BS02 peptide A H57 S195 H45 S182
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0043231 intracellular membrane-bounded organelle

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Biological Process
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Cellular Component
External links
PDB RCSB:2rdl, PDBe:2rdl, PDBj:2rdl
PDBsum2rdl
PubMed17981788
UniProtO70164

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