Structure of PDB 2rdd Chain A

Receptor sequence
>2rddA (length=1018) Species: 562 (Escherichia coli) [Search protein sequence]
MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYP
GADAKTVQDTVTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDA
DIAQVQVQNKLQLAMPLLPQEVQQQGVSVEKSSSSFLMVVGVINTDGTMT
QEDISDYVAANMKDAISRTSGVGDVQLFGSQYAMRIWMNPNELNKFQLTP
VDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRLTSTEEFGKIL
LKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLAANALDT
AAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVF
LVMYLFLQNFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAI
GLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMVLSAV
FVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIAK
KGFFGWFNRMFEKSTHHYTDSVGGILRSTGRYLVLYLIIVVGMAYLFVRL
PSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLTKEKNNVESV
FAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIK
DAMVFAFNLPAIVEFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMVRP
NGLEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRV
KKVYVMSEAKYRMLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLER
YNGLPSMEILGQAAPGKSTGEAMELMEQLASKLPTGVGYDWTGMSYQERL
SGNQAPSLYAISLIVVFLCLAALYESWSIPFSVMLVVPLGVIGALLAATF
RGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGLIEATLDAV
RMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLA
IFFVPVFFVVVRRRFSRK
3D structure
PDB2rdd Crystal structure of AcrB in complex with a single transmembrane subunit reveals another twist.
ChainA
Resolution3.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AIC A K29 A384 A385 F386 K29 A382 A383 F384
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0015125 bile acid transmembrane transporter activity
GO:0015562 efflux transmembrane transporter activity
GO:0015567 alkane transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0042802 identical protein binding
GO:0042910 xenobiotic transmembrane transporter activity
GO:0042931 enterobactin transmembrane transporter activity
Biological Process
GO:0009410 response to xenobiotic stimulus
GO:0009636 response to toxic substance
GO:0015721 bile acid and bile salt transport
GO:0015895 alkane transport
GO:0015908 fatty acid transport
GO:0042908 xenobiotic transport
GO:0042930 enterobactin transport
GO:0046677 response to antibiotic
GO:0055085 transmembrane transport
GO:0140330 xenobiotic detoxification by transmembrane export across the cell outer membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0098567 periplasmic side of plasma membrane
GO:1990281 efflux pump complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2rdd, PDBe:2rdd, PDBj:2rdd
PDBsum2rdd
PubMed18073115
UniProtP31224|ACRB_ECOLI Multidrug efflux pump subunit AcrB (Gene Name=acrB)

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