Structure of PDB 2rba Chain A

Receptor sequence
>2rbaA (length=182) Species: 9606 (Homo sapiens) [Search protein sequence]
TLPDILTFNLDIVIIGINPGLMAAYKGHHYPGPGNHFWKCLFMSGLSEVQ
LNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFREGGRILVQKLQKY
QPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIPDTETLCYVMPSS
SARCAQFPRAQDKVHYYIKLKDLRDQLKGIER
3D structure
PDB2rba Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition.
ChainA
Resolution2.79 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H151
Catalytic site (residue number reindexed from 1) H29
Enzyme Commision number 3.2.2.29: thymine-DNA glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A P155 K246 K248 A274 A277 P280 P33 K124 K126 A152 A155 P158
BS02 dna A N140 N157 S200 G231 K232 S271 S273 R275 C276 Q278 N18 N35 S78 G109 K110 S149 S151 R153 C154 Q156
Gene Ontology
Molecular Function
GO:0000700 mismatch base pair DNA N-glycosylase activity
Biological Process
GO:0006285 base-excision repair, AP site formation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2rba, PDBe:2rba, PDBj:2rba
PDBsum2rba
PubMed18587051
UniProtQ13569|TDG_HUMAN G/T mismatch-specific thymine DNA glycosylase (Gene Name=TDG)

[Back to BioLiP]