Structure of PDB 2ra0 Chain A

Receptor sequence
>2ra0A (length=234) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRF
KVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITF
RMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPY
VDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVT
GIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKT
3D structure
PDB2ra0 7-fluoroindazoles as potent and selective inhibitors of factor xa.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H42 D88 Q182 G183 D184 S185 G186
Enzyme Commision number 3.4.21.6: coagulation factor Xa.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JNJ A E97 T98 Y99 E146 D189 A190 C191 Q192 W215 G216 C220 E83 T84 Y85 E135 D179 A180 C181 Q182 W205 G206 C209 MOAD: Ki=15.9nM
PDBbind-CN: -logKd/Ki=7.80,Ki=15.9nM
BindingDB: Ki=15.9nM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2ra0, PDBe:2ra0, PDBj:2ra0
PDBsum2ra0
PubMed18159923
UniProtP00742|FA10_HUMAN Coagulation factor X (Gene Name=F10)

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