Structure of PDB 2r9z Chain A

Receptor sequence
>2r9zA (length=451) Species: 1048 (Marichromatium gracile) [Search protein sequence]
TQHFDLIAIGGGSGGLAVAEKAAAFGKRVALIESKALGGTCVNVGCVPKK
VMWYASHLAEAVRDAPGFGVQASLDWPRLVAGRDRYIGAINSFWDGYVER
LGITRVDGHARFVDAHTIEVEGQRLSADHIVIATGGRPIVPRLPGAELGI
TSDGFFALQQQPKRVAIIGAGYIGIELAGLLRSFGSEVTVVALEDRLLFQ
FDPLLSATLAENMHAQGIETHLEFAVAALERDAQGTTLVAQDGTRLEGFD
SVIWAVGRAPNTRDLGLEAAGIEVQSNGMVPTDAYQNTNVPGVYALGDIT
GRDQLTPVAIAAGRRLAERLFDGQSERKLDYDNIPTVVFAHPPLSKVGLS
EPEARERLGDVLTVYETSFTPMRYALNEHGPKTAMKLVCAGPEQRVVGVH
VIGDGADEMLQGFAVAVKMGATKADFDNTVAIHPGSAEELVTLKEPVRRP
G
3D structure
PDB2r9z Understanding nicotinamide dinucleotide cofactor and substrate specificity in class I flavoprotein disulfide oxidoreductases: crystallographic analysis of a glutathione amide reductase.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S14 L38 C42 C47 K50 Y176 E180 I314 A435 H437 E442
Catalytic site (residue number reindexed from 1) S13 L37 C41 C46 K49 Y172 E176 I310 A431 H433 E438
Enzyme Commision number 1.8.1.16: glutathione amide reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A G13 S14 G15 E34 S35 G40 T41 C42 G46 C47 K50 G112 H113 A114 T138 G139 Y176 R262 G301 D302 Q308 L309 T310 G12 S13 G14 E33 S34 G39 T40 C41 G45 C46 K49 G108 H109 A110 T134 G135 Y172 R258 G297 D298 Q304 L305 T306
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004362 glutathione-disulfide reductase (NADPH) activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0046872 metal ion binding
GO:0050660 flavin adenine dinucleotide binding
GO:0050661 NADP binding
Biological Process
GO:0006749 glutathione metabolic process
GO:0034599 cellular response to oxidative stress
GO:0045454 cell redox homeostasis
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:2r9z, PDBe:2r9z, PDBj:2r9z
PDBsum2r9z
PubMed17977556
UniProtD0VWY5|GASHR_MARGR Glutathione amide reductase (Gene Name=garB)

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