Structure of PDB 2r7w Chain A

Receptor sequence
>2r7wA (length=1073) Species: 10922 (Simian rotavirus) [Search protein sequence]
GKYNLILSEYLSFIYNSVQIPIYYSSNSELENRCIEFHSKCLENSKNGLS
LRKLFVEYNDVIENATLLSILSYSYDKYNAVERKLVKYAKGKPLEADLTV
NELDYENNKMTSELFPTAEEYTDSLMDPAILTSLSSNLNAVMFWLEKHEN
DVAEKLKVYKRRLDLFTIVASTINKYGVPRHNAKYRYEYDVMKDKPYYLV
TWANSSIEMLMSVFSHDDYLIAKELIVLSYSNRSTLAKLVSSPMSILVAL
VDINGTFITNEELELEFSNKYVRAIVPDQTFDELNQMLDNMRKAGLVDIP
KMIQDWLVDRSIEKFPLMAKIYSWSFHVGFRKQKMLDAALDQEMYREYTM
LIRDEVVKMLEEPVKHDDHLLRDSELAGLLSMSSASNGESRQLKFGRKTI
FSTKKNMHVMDDMANERYTPGIIPPVNVDKPIPLGRRDVPGRRTRIIFIL
PYEYFIAQHAVVEKMLIYAKHTREYAEFYSQSNQLLSYGDVTRFLSNNTM
VLYTDVSQWDSSQHNTQPFRKGIIMGLDILANMTNDAKVLQTLNLYKQTQ
INLMDSYVQIPDGNVIKKIQYGAVASGEKQTKAANSIANLALIKTVLSRI
SNKHSFATKIIRVDGDDNYAVLQFNTEVTKQMIQDVSNDVRETYARMNAK
VKALVSTVGIEIAKRYIAGGKIFFRAGINLLNNEKRGQSTQWDQAAILYS
NYIVNRLRGFETDREFILTKIMQMTSVAITGSLRLFPSERVLTTNSTFKV
FDSEDFIIEYGTTVDEVYIQRAFMSLSSQKSGIADEIAASSTFKNYVTRL
SEQLLFSKNNIVSRGIALTEKAKLNSYAPISLEKRRAQISALLTMLQKPV
TFKSSKITINDILRDIKPFFTVSDAHLPIQYQKFMPTLPDNVQYIIQCIG
SRTYQIEDDGSKSAISRLISKYSVYKPSIEELYKVISLHENEIQLYLISL
GIPKIDADTYVGSKIYSRDKYRILESYVYNLLSINYGCYQLFDFNSPDLE
KLIRIPFKGKIPAVTFILHLYAKLEVINYAIKNGSWISLFCNYPKSEMIK
LWKKMWNITSLRSPYTNANFFQE
3D structure
PDB2r7w Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1.
ChainA
Resolution2.6 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A K188 R190 S398 A400 S401 I415 F416 T418 K420 I462 G592 K594 R701 G702 Y842 P844 K184 R186 S383 A385 S386 I400 F401 T403 K405 I447 G577 K579 R686 G687 Y827 P829
BS02 GTP A Y16 Y82 S137 H185 Y189 R749 Y15 Y78 S133 H181 Y185 R734
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019079 viral genome replication
Cellular Component
GO:0044423 virion component

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2r7w, PDBe:2r7w, PDBj:2r7w
PDBsum2r7w
PubMed19000820
UniProtO37061|RDRP_ROTSP RNA-directed RNA polymerase

[Back to BioLiP]