Structure of PDB 2r7l Chain A

Receptor sequence
>2r7lA (length=355) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence]
MISKDEILEIFDKYNKDEITIATLGSHTSLHILKGAKLEGFSTVCITMKG
RDVPYKRFKVADKFIYVDNFSDIKNEEIQEKLRELNSIVVPHGSFIAYCG
LDNVENSFLVPMFGNRRILRWESERSLEGKLLREAGLRVPKKYESPEDID
GTVIVKFRGYFIASSTEEFYKKAEDLKKRGILTDEDIANAHIEEYVVGTN
FCIHYFYSPLKDEVELLGMDKRYESNIDGLVRIPAKDQLEMNINPSYVIT
GNIPVVIRESLLPQVFEMGDKLVAKAKELVPPGMIGPFCLQSLCNENLEL
VVFEMSARVDGGTNSFMNGGPYSFLYNGEPLSMGQRIAREIKMALQLDMI
DKIIS
3D structure
PDB2r7l Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.4.23: formate--phosphoribosylaminoimidazolecarboxamide ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A I154 K156 Y166 E199 Y201 V202 R228 E230 I255 Q297 L299 F309 E310 I154 K156 Y160 E193 Y195 V196 R222 E224 I249 Q291 L293 F303 E304
BS02 AMZ A H27 S94 R228 I255 N258 G317 H27 S94 R222 I249 N252 G311
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0016879 ligase activity, forming carbon-nitrogen bonds
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006188 IMP biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2r7l, PDBe:2r7l, PDBj:2r7l
PDBsum2r7l
PubMed18069798
UniProtQ57600|PURP_METJA 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase (Gene Name=purP)

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