Structure of PDB 2r7k Chain A

Receptor sequence
>2r7kA (length=358) Species: 2190 (Methanocaldococcus jannaschii) [Search protein sequence]
MISKDEILEIFDKYNKDEITIATLGSHTSLHILKGAKLEGFSTVCITMKG
RDVPYKRFKVADKFIYVDNFSDIKNEEIQEKLRELNSIVVPHGSFIAYCG
LDNVENSFLVPMFGNRRILRWESERSLEGKLLREAGLRVPKKYESPEDID
GTVIVKFPGARGYFIASSTEEFYKKAEDLKKRGILTDEDIANAHIEEYVV
GTNFCIHYFYSPLKDEVELLGMDKRYESNIDGLVRIPAKDQLEMNINPSY
VITGNIPVVIRESLLPQVFEMGDKLVAKAKELVPPGMIGPFCLQSLCNEN
LELVVFEMSARVDGGTNSFMNGGPYSFLYNGEPLSMGQRIAREIKMALQL
DMIDKIIS
3D structure
PDB2r7k Crystal structure and function of 5-formaminoimidazole-4-carboxamide ribonucleotide synthetase from Methanocaldococcus jannaschii.
ChainA
Resolution2.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 6.3.4.23: formate--phosphoribosylaminoimidazolecarboxamide ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACP A I154 K156 Y166 E199 Y201 V202 E230 L299 F309 E310 I154 K156 Y163 E196 Y198 V199 E227 L296 F306 E307
BS02 AMZ A H27 S94 I255 N258 G317 H27 S94 I252 N255 G314
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0016879 ligase activity, forming carbon-nitrogen bonds
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006188 IMP biosynthetic process
GO:0006189 'de novo' IMP biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2r7k, PDBe:2r7k, PDBj:2r7k
PDBsum2r7k
PubMed18069798
UniProtQ57600|PURP_METJA 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase (Gene Name=purP)

[Back to BioLiP]