Structure of PDB 2r7e Chain A

Receptor sequence
>2r7eA (length=693) Species: 9606 (Homo sapiens) [Search protein sequence]
ATRRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSFPFNTSVVYKKTL
FVEFTDHLFNIAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHA
VGVSYWKASEGAEYDDQTSQREKEDDKVFPGGSHTYVWQVLKENGPMASD
PLCLTYSYLSHVDLVKDLNSGLIGALLVCREGSLAKEKTQTLHKFILLFA
VFDEGKSWHSETKNAASARAWPKMHTVNGYVNRSLPGLIGCHRKSVYWHV
IGMGTTPEVHSIFLEGHTFLVRNHRQASLEISPITFLTAQTLLMDLGQFL
LFCHISSHQHDGMEAYVKVDSCPEEPQFDDDNSPSFIQIRSVAKKHPKTW
VHYIAAEEEDWDYAPLVLAPDDRSYKSQYLNNGPQRIGRKYKKVRFMAYT
DETFKTREAIQHESGILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGITD
VRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDGPTKSDPRCLTRY
YSSFVNMERDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFDEN
RSWYLTENIQRFLPNPAGVQLEDPEFQASNIMHSINGYVFDSLQLSVCLH
EVAYWYILSIGAQTDFLSVFFSGYTFKHKMVYEDTLTLFPFSGETVFMSM
ENPGLWILGCHNSDFRNRGMTALLKVSSCDKNTGDYYEDSYED
3D structure
PDB2r7e The tertiary structure and domain organization of coagulation factor VIII.
ChainA
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A A112 D116 K123 D126 A112 D116 K123 D126
BS02 CA A S535 F536 N538 E540 D542 S503 F504 N506 E508 D510
BS03 CA A K107 A108 D125 D126 K107 A108 D125 D126
BS04 CU A H267 I312 H315 H260 I305 H308
Gene Ontology
Molecular Function
GO:0005507 copper ion binding

View graph for
Molecular Function
External links
PDB RCSB:2r7e, PDBe:2r7e, PDBj:2r7e
PDBsum2r7e
PubMed17965321
UniProtP00451|FA8_HUMAN Coagulation factor VIII (Gene Name=F8)

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