Structure of PDB 2r72 Chain A

Receptor sequence
>2r72A (length=765) Species: 10995 (Infectious bursal disease virus) [Search protein sequence]
DVEELLIPKVWVPPEDPLASPSRLAKFLRENGYKVLQPRSLPENEEYETD
QILPDLAWMRQILKPTLSLPIGDQEYFPKYYPTHRPSKEKPNAYPPDIAL
LKQMIYLFLQVPEANEGLKDEVTLLTQNIRDKAYGSGTYMGQANRLVAMK
EVATGRNPNKDPLKLGYTFESIAQLLDITLPVGPPGDDKPWVPLTRVPSR
MLVLTGDVDVEDYLPKINLKSSSGLPYVGRTKGETIGEMIAISNQFLREL
STLLKQGAGTKGSNKKKLLSMLSDYWYLSCGLLFPKAERYDKSTWLTKTR
NIWSAPSPTHLMISMITWPVMSNSPNNVLNIEGCPSLYKFNPFRGGLNRI
VEWILAPEEPKALVYADNIYIVHSNTWYSIDLEKGEANCTRQHMQAAMYY
ILTRGWSDNGDPMFNQTWATFAMNIAPALVVDSSCLIMNLQIKTYGQGSG
NAATFINNHLLSTLVLDQWNLMRQPRPDSEEFKSIEDKLGINFKIERSID
DIRGKLRQLVLLAQPGYLSGGVEPEQSSPTVELDLLGWSATYSKDLGIYV
PVLDKERLFCSAAYPKGVENKSLKSKVGIEQAYKVVRYEALRLVGGWNYP
LLNKACKNNAGAARRHLEAKGFPLDEFLAEWSELSEFGEAFEGFNIKLTV
TSESLAELNKPVPPKPPNVNRPVNTGGLKAVSNALKTGRYRNEAGLSGLV
LLATARSRLQDAVKAKAEAEKLHKSKPDADWFERSETLSDLLEKADIASK
VAHSALVETSDALEA
3D structure
PDB2r72 Activation mechanism of a noncanonical RNA-dependent RNA polymerase.
ChainA
Resolution3.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D402 L417 K419 G420 D367 L382 K384 G385
BS02 MG A N403 Y405 I415 N368 Y370 I380
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005525 GTP binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0018144 RNA-protein covalent cross-linking
GO:0019079 viral genome replication
Cellular Component
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2r72, PDBe:2r72, PDBj:2r72
PDBsum2r72
PubMed18077388
UniProtQ9Q6Q5|RDRP_IBDV RNA-directed RNA polymerase (Gene Name=VP1)

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