Structure of PDB 2r6y Chain A

Receptor sequence
>2r6yA (length=232) Species: 9606 (Homo sapiens) [Search protein sequence]
LALSLTADQMVSALLDAEPPILYSEYDPSMMGLLTNLADRELVHMINWAK
RVPGFVDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLLDR
NQGKSVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFL
SSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILS
HIRHMSNKGMEHLYSMVPLYDLLLEMLDAHRL
3D structure
PDB2r6y Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LLC A T347 A350 D351 E353 W383 L387 F404 M421 I424 H524 L525 T35 A38 D39 E41 W71 L75 F92 M109 I112 H212 L213 MOAD: Ki=0.32nM
PDBbind-CN: -logKd/Ki=9.49,Ki=0.32nM
BindingDB: IC50=120nM
External links
PDB RCSB:2r6y, PDBe:2r6y, PDBj:2r6y
PDBsum2r6y
PubMed18474858
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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