Structure of PDB 2r6n Chain A

Receptor sequence
>2r6nA (length=216) Species: 9606 (Homo sapiens) [Search protein sequence]
RAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLS
PQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYN
PTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGV
YYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARN
KNNACGIANLASFPKM
3D structure
PDB2r6n Novel scaffold for cathepsin K inhibitors.
ChainA
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 C25 H162 N182
Catalytic site (residue number reindexed from 1) Q20 C26 H163 N183
Enzyme Commision number 3.4.22.38: cathepsin K.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CKE A G23 C25 G64 G65 G66 Y67 N161 G24 C26 G65 G66 G67 Y68 N162 PDBbind-CN: -logKd/Ki=9.00,IC50=1nM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2r6n, PDBe:2r6n, PDBj:2r6n
PDBsum2r6n
PubMed17911019
UniProtP43235|CATK_HUMAN Cathepsin K (Gene Name=CTSK)

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