Structure of PDB 2r4v Chain A

Receptor sequence
>2r4vA (length=226) Species: 9606 (Homo sapiens) [Search protein sequence]
VDPEIELFVKAGSDGESIGNCPFCQRLFMILWLKGVKFNVTTVDMTPGTN
PPFLVYNKELKTDFIKIEEFLEQTLAPPRYPHLSPKYKESFDVGCNLFAK
FSAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVS
RRLFLDGDQLTLADCSLLPKLNIIKVAAKKYRDFDIPAEFSGVWRYLHNA
YAREEFTHTCPEDKEIENTYANVAKQ
3D structure
PDB2r4v Structure of the Janus Protein Human CLIC2
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 GSH A E25 I27 F37 W41 H227 E16 I18 F28 W32 H208
BS02 GSH A A131 N134 F135 A112 N115 F116
Gene Ontology
Molecular Function
GO:0004364 glutathione transferase activity
GO:0004602 glutathione peroxidase activity
GO:0005254 chloride channel activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
Biological Process
GO:0006821 chloride transport
GO:0007165 signal transduction
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0034220 monoatomic ion transmembrane transport
GO:0051099 positive regulation of binding
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
GO:0098869 cellular oxidant detoxification
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034707 chloride channel complex

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:2r4v, PDBe:2r4v, PDBj:2r4v
PDBsum2r4v
PubMed17945253
UniProtO15247|CLIC2_HUMAN Chloride intracellular channel protein 2 (Gene Name=CLIC2)

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