Structure of PDB 2qzo Chain A

Receptor sequence
>2qzoA (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVLEE
KDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKG
MEHLYSMKCKNVVPLSDLLLEMLDAHRL
3D structure
PDB2qzo Coupling of receptor conformation and ligand orientation determine graded activity.
ChainA
Resolution1.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 L372 Q375 V376 E380 D538 L539 E542 I54 K58 L68 Q71 V72 E76 D217 L218 E221
BS02 KN1 A M343 E353 L387 M388 M421 F425 G521 H524 M39 E49 L83 M84 M110 F114 G200 H203 BindingDB: IC50=1300nM
External links
PDB RCSB:2qzo, PDBe:2qzo, PDBj:2qzo
PDBsum2qzo
PubMed20924370
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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