Structure of PDB 2qyk Chain A

Receptor sequence
>2qykA (length=334) Species: 9606 (Homo sapiens) [Search protein sequence]
MNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIF
QERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLL
ATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDE
SVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKH
MTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPL
ELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYI
VHPLWETWADLVHPDAQEILDTLEDNRDWYYSAI
3D structure
PDB2qyk Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NPV A Y371 H372 N533 I548 F552 M569 S580 Q581 F584 Y83 H84 N245 I260 F264 M281 S292 Q293 F296 MOAD: ic50=3.3uM
PDBbind-CN: -logKd/Ki=5.48,IC50=3.3uM
BindingDB: IC50=3300nM,EC50=20nM
BS02 ZN A H376 H412 D413 D530 H88 H124 D125 D242
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:2qyk, PDBe:2qyk, PDBj:2qyk
PDBsum2qyk
PubMed17727341
UniProtP27815|PDE4A_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4A (Gene Name=PDE4A)

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