Structure of PDB 2qxm Chain A

Receptor sequence

>2qxmA (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]

SLALSLTADQMVSALLDAEPPILYSEYRPFSEASMMGLLTNLADRELVHM
INWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPN
LLLDRNEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFL
KSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRH
MSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRL

3D structure

PDB

2qxm NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses

Chain

Resolution

2.3 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	I358 K362 L372 V376 D538 L539 E542	I51 K55 L65 V69 D222 L223 E226
BS02	PIQ	A	L391 M421 H524 L525	L84 M109 H208 L209

External links

PDB	RCSB:2qxm, PDBe:2qxm, PDBj:2qxm
PDBsum	2qxm
PubMed	18344977
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

[Back to BioLiP]