Structure of PDB 2qwg Chain A

Receptor sequence
>2qwgA (length=388) Species: 11320 (Influenza A virus) [Search protein sequence]
RDFNNLTKGLCTINSWHIYGKDNAVRIGEDSDVLVTREPYVSCDPDECRF
YALSQGTTIRGKHSNGTIHDRSQYRALISWPLSSPPTVYNSRVECIGWSS
TSCHDGKTRMSICISGPNNNASAVIWYNRRPVTEINTWARNILRTQESEC
VCHNGVCPVVFTDGSATGPAETRIYYFKEGKILKWEPLAGTAKHIEECSC
YGERAEITCTCKDNWQGSNRPVIRIDPVAMTHTSQYICSPVLTDNPRPND
PTVGKCNDPYPGNNNNGVKGFSYLDGVNTWLGRTISIASRSGYEMLKVPN
ALTDDKSKPTQGQTIVLNTDWSGYSGSFMDYWAEGECYRACFYVELIRGR
PKEDKVWWTSNSIVSMCSSTEFLGQWDWPDGAKIEYFL
3D structure
PDB2qwg Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase.
ChainA
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 E277 K292 R371 Y406
Catalytic site (residue number reindexed from 1) D70 E197 K212 R290 Y324
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D293 N294 G297 D324 N347 D213 N214 G217 D244 N266
BS02 G28 A R118 E119 D151 R152 W178 E276 E277 R371 Y406 R37 E38 D70 R71 W98 E196 E197 R290 Y324 MOAD: ic50=230uM
PDBbind-CN: -logKd/Ki=3.64,IC50=230uM
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0046761 viral budding from plasma membrane
Cellular Component
GO:0016020 membrane
GO:0033644 host cell membrane
GO:0055036 virion membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2qwg, PDBe:2qwg, PDBj:2qwg
PDBsum2qwg
PubMed9655825
UniProtP03472|NRAM_I75A5 Neuraminidase (Gene Name=NA)

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