Structure of PDB 2qvw Chain A

Receptor sequence
>2qvwA (length=732) Species: 5741 (Giardia intestinalis) [Search protein sequence]
GAMHALGHCCTVVTTRGPSHWLLLLDTHLGTLPGFKVSAGRGLPAAEVYF
EAGPRVSLSRTDATIVAVYQSILFQLLGPTFPASWTEIGATMPHNEYTFP
RFISNPPQFATLAFLPLLSPTSPLDLRALMVTAQLMCDAKRLSDELSASL
HGRMVATPEISWSLYVVLGIDSTQTSLSYFTRANESITYMRYYATAHNIH
LRAADLPLVAAVRLDDLKDHQIPAPGSDDLAPKLRFLPPELCLLLPDEFD
LIRVQALQFLPEIAKHICDIQNTICALDKSFPDCGRIGGERYFAITAGLR
LDQGRGRGLAGWRTPFGPFGVSHTDVFQRLELLGDAVLGFIVTARLLCLF
PDASVGTLVELKMELVRNEALNYLVQTLGLPQLAEFSNNLKSKTWADMYE
EIVGSIFTGPNGIYGCEEFLAKTLMSPEHSKTACPDAVTKASKRVCMGEA
GAHEFRSLVDYACEQGISVFCSSRVSTMFLERLRDIPAEDMLDWYRLGIQ
FSHRSGLSGPGGVVSVIDIMTHLARGLWLGSPGFYVEQPPTIPVLYIYHR
SVQCPVLYGSLTTGPVASKVLALYEKILAYESSGGSKHIAAQTVSRSLAV
PIPSGTIPFLIRLLQIALTPHVYQKLELLGDAFLKCSLALHLHALHPTLT
EGALTRMRQSAETNSVLGRLTKRFPSVVSEVIIESHPKIQPDSKVYGDTF
EAILAAILLACGEEAAGAFVREHVLPQVVADA
3D structure
PDB2qvw An unusual case of pseudo-merohedral twinning in orthorhombic crystals of Dicer
ChainA
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A E649 D720 E723 E627 D698 E701
BS02 MN A D653 E684 D631 E662
BS03 MN A H668 P669 T670 H646 P647 T648
BS04 MN A F355 P356 D357 F350 P351 D352
BS05 MN A N373 E374 N368 E369
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004525 ribonuclease III activity
GO:0046872 metal ion binding
Biological Process
GO:0006396 RNA processing
GO:0031047 regulatory ncRNA-mediated gene silencing

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Molecular Function
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Biological Process
External links
PDB RCSB:2qvw, PDBe:2qvw, PDBj:2qvw
PDBsum2qvw
PubMed17704568
UniProtA8BQJ3|DCL_GIAIC Endoribonuclease Dicer-like (Gene Name=GL50803_103887)

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