Structure of PDB 2qvn Chain A

Receptor sequence
>2qvnA (length=360) Species: 126793 (Plasmodium vivax Sal-1) [Search protein sequence]
LQEPIDFLKKEELKNIDLSQMSKKERYKIWKRIPKCELHCHLDLCFSADF
FVSCIRKYNLQPNLSDEEVLDYYLFAKGGKSLGEFVEKAIKVADIFHDYE
VIEDLAKHAVFNKYKEGVVLMEFRYSPTFVAFKYNLDIELIHQAIVKGIK
EVVELLDHKIHVALMCIGDTGHEAANIKASADFCLKHKADFVGFDHGGHE
VDLKEYKEIFDYVRESGVPLSVHAGEDVTLPNLNTLYSAIQVLKVERIGH
GIRVAESQELIDMVKEKNILLEVCPISNVLLKNAKSMDTHPIRQLYDAGV
KVSVNSDDPGMFLTNINDDYEELYTHLNFTLEDFMKMNEWALEKSFMDSN
IKDKIKNLYF
3D structure
PDB2qvn Structures of substrate- and inhibitor-bound adenosine deaminase from a human malaria parasite show a dramatic conformational change and shed light on drug selectivity.
ChainA
Resolution2.19 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H42 H44 H226 E229 H253 D310
Catalytic site (residue number reindexed from 1) H39 H41 H223 E226 H250 D307
Enzyme Commision number 3.5.4.31: S-methyl-5'-thioadenosine deaminase.
3.5.4.4: adenosine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GMP A H44 D46 L85 F88 D172 G201 H226 E229 D310 D311 H41 D43 L82 F85 D169 G198 H223 E226 D307 D308
Gene Ontology
Molecular Function
GO:0004000 adenosine deaminase activity
GO:0016787 hydrolase activity
GO:0019239 deaminase activity
GO:0046872 metal ion binding
GO:0046936 2'-deoxyadenosine deaminase activity
GO:0090614 5'-methylthioadenosine deaminase activity
Biological Process
GO:0006154 adenosine catabolic process
GO:0006166 purine ribonucleoside salvage
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0043103 hypoxanthine salvage
GO:0046103 inosine biosynthetic process
GO:0060169 negative regulation of adenosine receptor signaling pathway
Cellular Component
GO:0005829 cytosol
GO:0009897 external side of plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2qvn, PDBe:2qvn, PDBj:2qvn
PDBsum2qvn
PubMed18602399
UniProtA5KE01|ADA_PLAVS Adenosine deaminase (Gene Name=ADA)

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