Structure of PDB 2qv4 Chain A

Receptor sequence

>2qv4A (length=496) Species: 9606 (Homo sapiens) [Search protein sequence]

QYSPNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPPNENVA
IYNPFRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVIN
HMCGNAVSAGTSSTCGSYFNPGSRDFPAVPYSGWDFNDGKCKTGSGDIEN
YNDATQVRDCRLTGLLDLALEKDYVRSKIAEYMNHLIDIGVAGFRLDASK
HMWPGDIKAILDKLHNLNSNWFPAGSKPFIYQEVIDLGGEPIKSSDYFGN
GRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWGFVPSDRALVFVDNHD
NQRGHGAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWPRQFQN
GNDVNDWVGPPNNNGVIKEVTINPDTTCGNDWVCEHRWRQIRNMVIFRNV
VDGQPFTNWYDNGSNQVAFGRGNRGFIVFNNDDWSFSLTLQTGLPAGTYC
DVISGDKINGNCTGIKIYVSDDGKAHFSISNSAEDPFIAIHAESKL

3D structure

PDB

2qv4 Alternative catalytic anions differentially modulate human alpha-amylase activity and specificity

Chain

Resolution

1.97 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	D197 S226 D300
Catalytic site (residue number reindexed from 1)	D197 S226 D300
Enzyme Commision number	3.2.1.1: alpha-amylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	A	N100 R158 D167 H201	N100 R158 D167 H201
BS02	NO2	A	R195 T254 N298 R337	R195 T254 N298 R337
BS03	QV4	A	W58 W59 Y62 Q63 H101 G104 N105 A106 V107 L162 T163 G164 L165 R195 D197 H201 E233 I235 H299 D300	W58 W59 Y62 Q63 H101 G104 N105 A106 V107 L162 T163 G164 L165 R195 D197 H201 E233 I235 H299 D300

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity
GO:0004556	alpha-amylase activity
GO:0005509	calcium ion binding
GO:0016160	amylase activity
GO:0016798	hydrolase activity, acting on glycosyl bonds
GO:0031404	chloride ion binding
GO:0043169	cation binding
GO:0046872	metal ion binding

	Biological Process
GO:0005975	carbohydrate metabolic process
GO:0016052	carbohydrate catabolic process
GO:0044245	polysaccharide digestion

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0070062	extracellular exosome

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:2qv4, PDBe:2qv4, PDBj:2qv4
PDBsum	2qv4
PubMed	18284212
UniProt	P04746\|AMYP_HUMAN Pancreatic alpha-amylase (Gene Name=AMY2A)

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