Structure of PDB 2qt0 Chain A

Receptor sequence
>2qt0A (length=179) Species: 9606 (Homo sapiens) [Search protein sequence]
RGSKTFIIGISGVTNSGKTTLAKNLQKHLPNCSVISQDDFFKPESEIETD
KNGFLQYDVLEALNMEKMMSAISCWMESARHSVIPILIIEGFLLFNYKPL
DTIWNRSYFLTIPYEECKRRRSTRVYQPPDSPGYFDGHVWPMYLKYRQEM
QDITWEVVYLDGTKSEEDLFLQVYEDLIQ
3D structure
PDB2qt0 Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD(+).
ChainA
Resolution1.92 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.173: nicotinate riboside kinase.
2.7.1.22: ribosylnicotinamide kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T17 D36 T19 D38
BS02 ANP A T12 N13 G15 K16 T17 T18 D36 R128 R132 Y134 K172 E174 T14 N15 G17 K18 T19 T20 D38 R120 R124 Y126 K164 E166
BS03 NNR A F39 Y55 D56 F100 R129 Y134 F41 Y57 D58 F92 R121 Y126
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0034317 nicotinate riboside kinase activity
GO:0046872 metal ion binding
GO:0050262 ribosylnicotinamide kinase activity
GO:0061769 ribosylnicotinate kinase activity
Biological Process
GO:0009435 NAD biosynthetic process
GO:0016310 phosphorylation
GO:0019363 pyridine nucleotide biosynthetic process
GO:0019674 NAD metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:2qt0, PDBe:2qt0, PDBj:2qt0
PDBsum2qt0
PubMed17914902
UniProtQ9NWW6|NRK1_HUMAN Nicotinamide riboside kinase 1 (Gene Name=NMRK1)

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