Structure of PDB 2qs4 Chain A

Receptor sequence
>2qs4A (length=256) Species: 10116 (Rattus norvegicus) [Search protein sequence]
SNRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLY
DVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDF
SKPFMTLGISILYRKGTPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKI
STYEKMWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRN
CNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWW
RGNGCP
3D structure
PDB2qs4 Binding site and ligand flexibility revealed by high resolution crystal structures of GluK1 competitive antagonists.
ChainA
Resolution1.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LY5 A Y61 P88 T90 R95 S141 T142 S173 M189 E190 Y216 Y60 P87 T89 R94 S140 T141 S172 M188 E189 Y215 MOAD: Kd=38nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:2qs4, PDBe:2qs4, PDBj:2qs4
PDBsum2qs4
PubMed20558186
UniProtP22756|GRIK1_RAT Glutamate receptor ionotropic, kainate 1 (Gene Name=Grik1)

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