Structure of PDB 2qrv Chain A

Receptor sequence
>2qrvA (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]
PAEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVR
HQGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEG
TGRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESN
PVMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAK
FSKVRQHFPVFMNEKEDILWCTEMERVFGFPVHYTDVSNMSRLARQRLLG
RSWSVPVIRHLFAPLKEYFACV
3D structure
PDB2qrv Structure of Dnmt3a bound to Dnmt3L suggests a model for de novo DNA methylation.
ChainA
Resolution2.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A F636 G638 T641 S659 E660 V661 C662 D682 V683 R684 P705 L726 R887 S888 W889 F14 G16 T19 S37 E38 V39 C40 D60 V61 R62 P83 L104 R251 S252 W253 BindingDB: IC50=>50000nM
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:2qrv, PDBe:2qrv, PDBj:2qrv
PDBsum2qrv
PubMed17713477
UniProtQ9Y6K1|DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (Gene Name=DNMT3A)

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