Structure of PDB 2qr9 Chain A

Receptor sequence

>2qr9A (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]

SLALSLTADQMVSALLDAEPPILYSEYRPFSEASMMGLLTNLADRELVHM
INWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPN
LLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSG
VYTFLSSTLKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQL
LLILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHRL

3D structure

PDB

2qr9 NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses

Chain

Resolution

2.0 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	I358 K362 L372 V376 D538 L539 E542	I51 K55 L65 V69 D231 L232 E235
BS02	HZ3	A	M343 T347 A350 E353 L387 F404 M421 F425 L428 H524 L540	M36 T40 A43 E46 L80 F97 M114 F118 L121 H217 L233

External links

PDB	RCSB:2qr9, PDBe:2qr9, PDBj:2qr9
PDBsum	2qr9
PubMed	18344977
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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