Structure of PDB 2qqs Chain A

Receptor sequence
>2qqsA (length=109) Species: 9606 (Homo sapiens) [Search protein sequence]
QSITAGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDI
VSQDCLQFGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQL
VVKRDDVYT
3D structure
PDB2qqs Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor.
ChainA
Resolution2.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.66: [histone H3]-trimethyl-L-lysine(9) demethylase.
1.14.11.69: [histone H3]-trimethyl-L-lysine(36) demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E959 E961 E63 E65
BS02 peptide A N931 F932 D934 G935 S936 F937 D939 W967 T968 D969 Y973 N35 F36 D38 G39 S40 F41 D43 W71 T72 D73 Y77
External links
PDB RCSB:2qqs, PDBe:2qqs, PDBj:2qqs
PDBsum2qqs
PubMed18084306
UniProtO75164|KDM4A_HUMAN Lysine-specific demethylase 4A (Gene Name=KDM4A)

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