Structure of PDB 2qq7 Chain A

Receptor sequence
>2qq7A (length=251) Species: 9031 (Gallus gallus) [Search protein sequence]
KDAWEIPRESLRLEVKLGQGFGEVWMGTWNGTTRVAIKTLQEAQVMKKLR
HEKLVQLYAVVSEEPIYIVMEYMSKGCLLDFLKGEMGKYLRLPQLVDMAA
QIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLPIKWTAPE
AALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP
CPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGEN
L
3D structure
PDB2qq7 Structural insights into how irreversible inhibitors can overcome drug resistance in EGFR.
ChainA
Resolution2.38 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404
Catalytic site (residue number reindexed from 1) D118 R120 A122 N123 D136
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SR2 A A293 K295 E310 M338 M341 G344 C345 L347 D348 L393 D404 A36 K38 E42 M70 M73 G76 C77 L79 D80 L125 D136 PDBbind-CN: -logKd/Ki=5.24,IC50=5.71uM
BindingDB: IC50=>27000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2qq7, PDBe:2qq7, PDBj:2qq7
PDBsum2qq7
PubMed18316192
UniProtP00523|SRC_CHICK Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)

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