Structure of PDB 2qpt Chain A

Receptor sequence
>2qptA (length=476) Species: 10090 (Mus musculus) [Search protein sequence]
RTVTSSLKELYRTKLLPLEEHYRFGSFHSPALEDADFDGKPMVLVAGQYS
TGKTSFIQYLLEQEVPGSRVGPEPTTDCFVAVMHGETEGTVPGNTFLNRF
MCAQLPNQVLESISIIDTPGILSRGYDFPAVLRWFAERVDLIILLFDAHK
LEISDEFSEAIGALRGHEDKIRVVLNKADMVETQQLMRVYGALMWALGKV
VGTPEVLRVYIGSFWSQPLLVPDNRRLFELEEQDLFRDIQGLPRHAALRK
LNDLVKRARLVRVHAYIISYLKKEMPTVFGKENKKKQLILKLPVIFAKIQ
LEHHISPGDFPDCQKMQELLMAHDFTKFHSLKPKLLEALDDMLAQDIAKL
MPLLRQEELESVEAGVAGGAFEGTRMGPFVEWVVTKDKSKYDEIFYNLAP
ADGKLSGSKAKTWMVGTKLPNSVLGRIWKLSDVDRDGMLDDEEFALASHL
IEAKLEGHGLPTNLPRRLVPPSKRRQ
3D structure
PDB2qpt Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A D494 D496 D498 M500 E505 D432 D434 D436 M438 E443
BS02 ANP A S68 G70 K71 T72 S73 V88 G89 K220 S256 W258 S50 G52 K53 T54 S55 V70 G71 K177 S213 W215
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0019904 protein domain specific binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006897 endocytosis
GO:0030866 cortical actin cytoskeleton organization
GO:0032456 endocytic recycling
GO:0072659 protein localization to plasma membrane
GO:0097320 plasma membrane tubulation
GO:1901741 positive regulation of myoblast fusion
GO:2001137 positive regulation of endocytic recycling
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0010008 endosome membrane
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0045171 intercellular bridge
GO:0048471 perinuclear region of cytoplasm
GO:0055038 recycling endosome membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2qpt, PDBe:2qpt, PDBj:2qpt
PDBsum2qpt
PubMed17914359
UniProtQ8BH64|EHD2_MOUSE EH domain-containing protein 2 (Gene Name=Ehd2)

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