Structure of PDB 2qpk Chain A

Receptor sequence

>2qpkA (length=595) Species: 9913 (Bos taurus)

SWEVGCGAPVPLVKCDENSPYRTITGDCNNRRSPALGAANRALARWLPAE
YEDGLALPFGWTQRKTRNGFRVPLAREVSNKIVGYLDEEGVLDQNRSLLF
MQWGQIVDHDLDFAPETELGSNEHSKTQCEEYCIQGDNCFPIMFPKNDPK
LKTQGKCMPFFRAGFVCPTPPYQSLAREQINAVTSFLDASLVYGSEPSLA
SRLRNLSSPLGLMAVNQEAWDHGLAYLPFNNKKPSPCEFINTTARVPCFL
AGDFRASEQILLATAHTLLLREHNRLARELKKLNPHWNGEKLYQEARKIL
GAFIQIITFRDYLPIVLGSEMQKWIPPYQGYNNSVDPRISNVFTFAFRFG
HMEVPSTVSRLDENYQPWGPEAELPLHTLFFNTWRIIKDGGIDPLVRGLL
AKKSKLMNQDKMVTSELRNKLFQPTHKIHGFDLAAINLQRCRDHGMPGYN
SWRGFCGLSQPKTLKGLQTVLKNKILAKKLMDLYKTPDNIDIWIGGNAEP
MVERGRVGPLLACLLGRQFQQIRDGDRFWWENPGVFTEKQRDSLQKVSFS
RLICDNTHITKVPLHAFQANNYPHDFVDCSTVDKLDLSPWASREN

3D structure

• PDB: 2qpk Structure of bovine lactoperoxidase with a partially linked heme moiety at 1.98 angstrom resolution.
• Chain: A
• Resolution: 2.34 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): Q105 D108 H109 D110 T184 F186 D188 S190 R255 E258 H351
• Catalytic site (residue number reindexed from 1): Q105 D108 H109 D110 T184 F186 D188 S190 R255 E258 H351
• Enzyme Commision number: 1.11.1.7: peroxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	D110 T184 F186 D188 S190	D110 T184 F186 D188 S190
BS02	HEM	A	M101 G104 Q105 D108 D112 F113 E258 F347 R348 G350 H351 I436 R440	M101 G104 Q105 D108 D112 F113 E258 F347 R348 G350 H351 I436 R440
BS03	SHA	A	H109 R255 E258	H109 R255 E258	BindingDB: IC50=4.0e+2nM

Gene Ontology

Molecular Function

• GO:0004601 peroxidase activity
• GO:0020037 heme binding

Biological Process

• GO:0006979 response to oxidative stress

External links

• PDB: RCSB:2qpk, PDBe:2qpk, PDBj:2qpk
• PDBsum: 2qpk
• PubMed: 27986533
• UniProt: P80025|PERL_BOVIN Lactoperoxidase (Gene Name=LPO)