Structure of PDB 2qpd Chain A

Receptor sequence

>2qpdA (length=557) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]

SEISRVYEAYPEKKATLYFLVLGFLALIVGSLFGPFQALNYGNVDAYPLL
KRLLPFVQSYYQGLTLHGVLNAIVFTQLFAQAIMVYLPARELNMRPNMGL
MWLSWWMAFIGLVVAALPLLANEATVLYTFYPPLKGHWAFYLGASVFVLS
TWVSIYIVLDLWRRWKAANPGKVTPLVTYMAVVFWLMWFLASLGLVLEAV
LFLLPWSFGLVEGVDPLVARTLFWWTGHPIVYFWLLPAYAIIYTILPKQA
GGRLVSDPMARLAFLLFLLLSTPVGFHHQFADPGIDPTWKMIHSVLTLFV
AVPSLMTAFTVAASLEFAGRLRGGRGLFGWIRALPWDNPAFVAPVLGLLG
FIPGGAGGIVNASFTLDYVVHNTAWVPGHFHLQVASLVTLTAMGSLYWLL
PNLTGKPISDAQRRLGLAVVWLWFLGMMIMAVGLHWAGLLNVPRRAYIAQ
VPDAYPHAAVPMVFNVLAGIVLLVALLLFIYGLFSVLLSRERKPELAEAP
LPFAEVISGPEDRRLVLAMDRIGFWFAVAAILVVLAYGPTLVQLFGHLNP
VPGWRLW

3D structure

PDB

2qpd An unexpected outcome of surface engineering an integral membrane protein: improved crystallization of cytochrome ba(3) from Thermus thermophilus.

Chain

Resolution

3.25 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	H72 P101 Y133 S155 T156 H233 I235 Y237 Y248 H282 H283 S309 G331 H384 F385 H386 R449 R450
Catalytic site (residue number reindexed from 1)	H67 P96 Y128 S150 T151 H228 I230 Y232 Y243 H277 H278 S304 G326 H379 F380 H381 R444 R445
Enzyme Commision number	7.1.1.9: cytochrome-c oxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CU1	A	H233 H282 H283	H228 H277 H278
BS02	HEM	A	G39 P40 Q42 A43 Y46 Y65 L69 H72 N76 Y133 F385 H386 V389 A390 M435 R450	G34 P35 Q37 A38 Y41 Y60 L64 H67 N71 Y128 F380 H381 V384 A385 M430 R445
BS03	HAS	A	Y133 V236 Y237 W239 L240 H282 H283 S309 A313 L353 L354 F356 G360 G363 N366 D372 H376 V381 H384 F385 Q388 V389 R449	Y128 V231 Y232 W234 L235 H277 H278 S304 A308 L348 L349 F351 G355 G358 N361 D367 H371 V376 H379 F380 Q383 V384 R444

Gene Ontology

	Molecular Function
GO:0004129	cytochrome-c oxidase activity
GO:0020037	heme binding
GO:0046872	metal ion binding

	Biological Process
GO:0006119	oxidative phosphorylation
GO:0009060	aerobic respiration
GO:1902600	proton transmembrane transport

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

View graph for
Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:2qpd, PDBe:2qpd, PDBj:2qpd
PDBsum	2qpd
PubMed	18084085
UniProt	Q5SJ79\|COX1_THET8 Cytochrome c oxidase subunit 1 (Gene Name=cbaA)

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