Structure of PDB 2qoq Chain A

Receptor sequence
>2qoqA (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
TYVDPHEDPTQTVHEFAKELDATNISIDKVVGAGEFGEVCSGRLKLPSKK
EISVAIKTLKVGYTEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKSKPVM
IVTEYMENGSLDSFLRKHDAQFTVIQLVGMLRGIASGMKYLSDMGYVHRD
LAARNILINSNLVCKVSDFGKIPIRWTSPEAIAYRKFTSASDVWSYGIVL
WEVMSYGERPYWEMSNQDVIKAVDEGYRLPPPMDCPAALYQLMLDCWQKD
RNNRPKFEQIVSILDKLIRNPGSLKIITNLLLDQS
3D structure
PDB2qoq Autoregulation by the Juxtamembrane Region of the Human Ephrin Receptor Tyrosine Kinase A3 (EphA3).
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D746 A748 R750 N751 D764
Catalytic site (residue number reindexed from 1) D150 A152 R154 N155 D168
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A A651 M702 S706 A55 M106 S110
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2qoq, PDBe:2qoq, PDBj:2qoq
PDBsum2qoq
PubMed18547520
UniProtP29320|EPHA3_HUMAN Ephrin type-A receptor 3 (Gene Name=EPHA3)

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