Structure of PDB 2qo0 Chain A

Receptor sequence
>2qo0A (length=328) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQEWIYTRTGIKTRRFAA
DDESAASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAPMVAA
SLGAKGILGFDLSAGCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTI
DMYDRGNCFIFADGAAAVVVGETPFQGIGPTVAGSDGEQADAIRQDIDWI
TFAQNPSGPRPFVRLEGPAVFRWAAFKMGDVGRRAMDAAGVRPDQIDVFV
PHQFNSRINELLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMAELLTTG
AAKPGDLALLIGYGAGLSYAAQVVRMPK
3D structure
PDB2qo0 Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.301: mycobacterial beta-ketoacyl-[acyl carrier protein] synthase III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 D1T A N81 C112 T145 Q191 F204 V205 A306 N85 C116 T149 Q195 F212 V213 A315
BS02 D1T A Q86 T87 Q90 T91
Gene Ontology
Molecular Function
GO:0000062 fatty-acyl-CoA binding
GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity
GO:0005515 protein binding
GO:0016746 acyltransferase activity
GO:0033818 beta-ketoacyl-acyl-carrier-protein synthase III activity
GO:0061990 beta-ketodecanoyl-[acyl-carrier-protein] synthase activity
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0008610 lipid biosynthetic process
GO:0030497 fatty acid elongation
GO:0035336 long-chain fatty-acyl-CoA metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2qo0, PDBe:2qo0, PDBj:2qo0
PDBsum2qo0
PubMed18420147
UniProtP9WNG3|FABH_MYCTU Mycobacterial beta-ketoacyl-[acyl-carrier-protein] synthase III (Gene Name=fabH)

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