Structure of PDB 2qlu Chain A

Receptor sequence
>2qluA (length=297) Species: 9606 (Homo sapiens) [Search protein sequence]
GSLQLLEIKARGRFGCVWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTP
GMKHENLLQFIAAEKRGSNLEVELWLITAFHDKGSLTDYLKGNIITWNEL
CHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVL
ADFGLAVRFEPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMY
AMGLVLWELVSRCKAADGPVDEYMLPFEEEIGQHPSLEELQEVVVHKKMR
PTIKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRS
3D structure
PDB2qlu Crystal structure of activin receptor type IIB kinase domain from human at 2.0 Angstrom resolution
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D321 K323 N326 D339 T361
Catalytic site (residue number reindexed from 1) D134 K136 N139 D152 T174
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADE A A215 L245 A266 F267 H268 L328 A28 L58 A79 F80 H81 L141
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:2qlu, PDBe:2qlu, PDBj:2qlu
PDBsum2qlu
PubMed17893364
UniProtQ13705|AVR2B_HUMAN Activin receptor type-2B (Gene Name=ACVR2B)

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