Structure of PDB 2qkx Chain A

Receptor sequence

>2qkxA (length=388) Species: 83332 (Mycobacterium tuberculosis H37Rv)

TFPGDTAVLVLAAGPGTRMRSDTPKVLHTLAGRSMLSHVLHAIAKLAPQR
LIVVLGHDHQRIAPLVGELADTLGRTIDVALQDRPLGTGHAVLCGLSALP
DDYAGNVVVTSGDTPLLDADTLADLIATHRAVSAAVTVLTTTLDDPFGYG
RILRTQDHEVMAIVEQTDATPSQREIREVNAGVYAFDIAALRSALSRLSS
NNAQQELYLTDVIAILRSDGQTVHASHVDDSALVAGVNNRVQLAELASEL
NRRVVAAHQLAGVTVVDPATTWIDVDVTIGRDTVIHPGTQLLGRTQIGGR
CVVGPDTTLTDVAVGDGASVVRTHGSSSSIGDGAAVGPFTYLRPGTALGA
DGKLGAFVEVKNSTIGTGTKVPHLTYVGDADIGEYSNI

3D structure

• PDB: 2qkx Structure and function of GlmU from Mycobacterium tuberculosis.
• Chain: A
• Resolution: 2.75 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): R19
• Catalytic site (residue number reindexed from 1): R18
• Enzyme Commision number: 2.3.1.157: glucosamine-1-phosphate N-acetyltransferase.
  2.7.7.23: UDP-N-acetylglucosamine diphosphorylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GN1	A	T89 Y150 G151 E166 N181 T211	T88 Y149 G150 E165 N180 T210

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity
• GO:0019134 glucosamine-1-phosphate N-acetyltransferase activity

Biological Process

• GO:0000902 cell morphogenesis
• GO:0006048 UDP-N-acetylglucosamine biosynthetic process
• GO:0009252 peptidoglycan biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2qkx, PDBe:2qkx, PDBj:2qkx
• PDBsum: 2qkx
• PubMed: 19237750
• UniProt: P9WMN3|GLMU_MYCTU Bifunctional protein GlmU (Gene Name=glmU)