Structure of PDB 2qkk Chain A

Receptor sequence

>2qkkA (length=154) Species: 9606 (Homo sapiens) [Search protein sequence]

GSHMGDFVVVYTDGCCSSNGRRRPRAGIGVYWGPGHPLNVGIRLPGRQTN
QRAEIHAACKAIEQAKTQNINKLVLYTNSMFTINGITNWVQGWKKNGWKT
SAGKEVINKEDFVALERLTQGMDIQWMHVPGHSGFIGNEEADRLAREGAK
QSED

3D structure

PDB

2qkk Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription

Chain

Resolution

3.2 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.26.4: ribonuclease H.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	A	C147 C148 S149 S150 N151 R153 N182 N210 M212 H260 P262 G263 R278	C15 C16 S17 S18 N19 R21 N50 N78 M80 H128 P130 G131 R146
BS02	dna	A	N151 G152 R179 T181 N182 Q183 F213 W221 W225 T232 S233 V238 I239 N240	N19 G20 R47 T49 N50 Q51 F81 W89 W93 T100 S101 V106 I107 N108
BS03	CA	A	D145 E186 N210	D13 E54 N78
BS04	CA	A	D145 D274	D13 D142

Gene Ontology

	Molecular Function
GO:0003676	nucleic acid binding
GO:0004523	RNA-DNA hybrid ribonuclease activity

View graph for
Molecular Function

External links

PDB	RCSB:2qkk, PDBe:2qkk, PDBj:2qkk
PDBsum	2qkk
PubMed	17964265
UniProt	O60930\|RNH1_HUMAN Ribonuclease H1 (Gene Name=RNASEH1)

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