Structure of PDB 2qkb Chain A

Receptor sequence
>2qkbA (length=152) Species: 9606 (Homo sapiens) [Search protein sequence]
GSHMGDFVVVYTDGCCSSNGRRRPRAGIGVYWGPGHPLNVGIRLPGRQTN
QRAEIHAACKAIEQAKTQNINKLVLYTNSMFTINGITNWVQGWKKNGWKT
SAGKEVINKEDFVALERLTQGMDIQWMHVPGHSGFIGNEEADRLAREGAK
QS
3D structure
PDB2qkb Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.4: ribonuclease H.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A D145 G146 C147 C148 S150 N151 R153 N182 E186 N210 M212 H260 P262 R278 D13 G14 C15 C16 S18 N19 R21 N50 E54 N78 M80 H128 P130 R146
BS02 dna A N151 G152 R179 T181 N182 Q183 W221 W225 T232 S233 V238 I239 N240 N19 G20 R47 T49 N50 Q51 W89 W93 T100 S101 V106 I107 N108
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:2qkb, PDBe:2qkb, PDBj:2qkb
PDBsum2qkb
PubMed17964265
UniProtO60930|RNH1_HUMAN Ribonuclease H1 (Gene Name=RNASEH1)

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