Structure of PDB 2qk9 Chain A

Receptor sequence
>2qk9A (length=153) Species: 9606 (Homo sapiens) [Search protein sequence]
SHMGDFVVVYTDGCCSSNGRRRPRAGIGVYWGPGHPLNVGIRLPGRQTNQ
RAEIHAACKAIEQAKTQNINKLVLYTNSMFTINGITNWVQGWKKNGWKTS
AGKEVINKEDFVALERLTQGMDIQWMHVPGHSGFIGNEEADRLAREGAKQ
SED
3D structure
PDB2qk9 Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.4: ribonuclease H.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A C147 C148 S150 N151 R153 N182 E186 N210 M212 A234 K236 H260 P262 R278 C14 C15 S17 N18 R20 N49 E53 N77 M79 A101 K103 H127 P129 R145
BS02 dna A N151 G152 R179 T181 N182 Q183 F213 W221 W225 S233 V238 I239 N240 N18 G19 R46 T48 N49 Q50 F80 W88 W92 S100 V105 I106 N107
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:2qk9, PDBe:2qk9, PDBj:2qk9
PDBsum2qk9
PubMed17964265
UniProtO60930|RNH1_HUMAN Ribonuclease H1 (Gene Name=RNASEH1)

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