Structure of PDB 2qir Chain A

Receptor sequence
>2qirA (length=172) [Search protein sequence]
SVTLRLMTEHDLAMLYEWLNRSHIVEWWARPTLADVQEQYLPSVLAQESV
TPYIAMLNGEPIGYAQSYVALGSGDGWWEEETDPGVRGIDQLLANASQLG
KGLGTKLVRALVELLFNDPEVTKIQTDPSPSNLRAIRCYEKAGFERQGTV
TTPDGPAVYMVQTRQAFERTRS
3D structure
PDB2qir Enzyme structural plasticity and the emergence of broad-spectrum antibiotic resistance.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.82: aminoglycoside 6'-N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 COA A W38 Q106 L107 L108 L114 G115 G117 G119 T120 L148 R149 R152 C153 K156 W27 Q91 L92 L93 L99 G100 G102 G104 T105 L133 R134 R137 C138 K141
BS02 9CS A W39 Y83 S88 W92 D105 D142 W28 Y68 S73 W77 D90 D127
Gene Ontology
Molecular Function
GO:0016410 N-acyltransferase activity
GO:0016740 transferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
Biological Process
GO:0046677 response to antibiotic

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Molecular Function
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Biological Process
External links
PDB RCSB:2qir, PDBe:2qir, PDBj:2qir
PDBsum2qir
PubMed18292754
UniProtQ8GLI5

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