Structure of PDB 2qhf Chain A

Receptor sequence
>2qhfA (length=392) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
MLRWITAGESHGRALVAVVEGMVAGVHVTSADIADQLARRRLGYGRGARM
TFERDAVTVLSGIRHGSTLGGPIAIEIGNTEWPKWETVMAADPVDPAELA
DVARNAPLTRPRPGHADYAGMLKYGFDDARPVLERASARETAARVAAGTV
ARAFLRQALGVEVLSHVISIGASAPYEGPPPRAEDLPAIDASPVRAYDKA
AEADMIAQIEAAKKDGDTLGGVVEAVALGLPVGLGSFTSGDHRLDSQLAA
AVMGIQAIKGVEIGDGFQTARRRGSRAHDEMYPGPDGVVRSTNRAGGLEG
GMTNGQPLRVRAAMKPISTVPRALATVDLATGDEAVAIHQRSDVCAVPAA
GVVVETMVALVLARAALEKFGGDSLAETQRNIAAYQRSVADR
3D structure
PDB2qhf Mycobacterium tuberculosis Chorismate synthase in complex with NCA
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.2.3.5: chorismate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NCA A R46 A138 I255 Q256 M314 I317 R341 R46 A138 I255 Q256 M314 I317 R341
Gene Ontology
Molecular Function
GO:0004107 chorismate synthase activity
GO:0010181 FMN binding
GO:0016651 oxidoreductase activity, acting on NAD(P)H
GO:0016829 lyase activity
GO:0051287 NAD binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2qhf, PDBe:2qhf, PDBj:2qhf
PDBsum2qhf
PubMed
UniProtP9WPY1|AROC_MYCTU Chorismate synthase (Gene Name=aroC)

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