Structure of PDB 2qh6 Chain A

Receptor sequence

>2qh6A (length=232) Species: 9606 (Homo sapiens) [Search protein sequence]

NSLALSLTADQMVSALLDAEPPILYSEYDRPFSEASMMGLLTNLADRELV
HMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFA
PNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLN
SGVYTFKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIR
HMSNKGMEHLYSMKCKNVPLSDLLLEMLDAHR

3D structure

PDB

2qh6 NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses

Chain

Resolution

2.7 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	I358 K362 L372 L379 E380 L539 E542	I53 K57 L67 L74 E75 L223 E226
BS02	ODE	A	M343 T347 E353 F404 M421 F425 G521 H524 L525	M38 T42 E48 F99 M116 F120 G206 H209 L210	PDBbind-CN: -logKd/Ki=6.00,IC50=1uM

External links

PDB	RCSB:2qh6, PDBe:2qh6, PDBj:2qh6
PDBsum	2qh6
PubMed	18344977
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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