Structure of PDB 2qe2 Chain A

Receptor sequence
>2qe2A (length=521) Species: 31647 (Hepatitis C virus subtype 1b) [Search protein sequence]
LLRHHNMVYATTSRSAGLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVK
AKLLSVEEACKLTPPHSAFGYGAKDVRNLSSKAVNHIHSVWKDLLEDPID
TTIMAKNEVFCVQPEGGRKPARLIVFPDLGVRVCEKMALYDVVSTLPQVV
MGSSYGFQYSPGQRVEFLVNTWKSKKNPMGFSYDTRCFDSTVTENDIRVE
ESIYQCCDLAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVLT
TSCGNTLTCYLKASAACRAAKLQDCTMLVNGDDLVVICESAGTQEDAASL
RVFTEAMTRYPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDP
TTPLARAAWETARHTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQ
LEKALDCQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRVASC
LRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYLFNWAVKTKLKLTP
IPAASLSGWFVAGYSGGDIYH
3D structure
PDB2qe2 Identification of Anthranilic Acid Derivatives as a Novel Class of Allosteric Inhibitors of Hepatitis C NS5B Polymerase
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.98: hepacivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 452 A P197 R200 C366 R386 G410 N411 M414 Y415 Q446 Y448 P161 R164 C328 R348 G372 N373 M376 Y377 Q408 Y410 PDBbind-CN: -logKd/Ki=7.77,IC50=17nM
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:2qe2, PDBe:2qe2, PDBj:2qe2
PDBsum2qe2
PubMed17402724
UniProtQ99AU2

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