Structure of PDB 2qcu Chain A

Receptor sequence

>2qcuA (length=499) Species: 562 (Escherichia coli) [Search protein sequence]

TKDLIVIGGGINGAGIAADAAGRGLSVLMLEAQDLACATSSASSKLIHGG
LRYLEHYEFRLVSEALAEREVLLKMAPHIAFPMRFRLPHRPHLRPAWMIR
IGLFMYDHLGKRTSLPGSTGLRFGANSVLKPEIKRGFEYSDCWVDDARLV
LANAQMVVRKGGEVLTRTRATSARRENGLWIVEAEDIDTGKKYSWQARGL
VNATGPWVKQFFDDGMHLPSPYGIRLIKGSHIVVPRVHTQKQAYILQNED
KRIVFVIPWMDEFSIIGTTDVEYKGDPKAVKIEESEINYLLNVYNTHFKK
QLSRDDIVWTYSGVRPLCDDESDSPQAITRDYTLDIHDENGKAPLLSVFG
GKLTTYRKLAEHALEKLTPYYQGIGPAWTKESVLPGGAIEGDRDDYAARL
RRRYPFLTESLARHYARTYGSNSELLLGNAGTVSDLGEDFGHEFYEAELK
YLVDHEWVRRADDALWRRTKQGMWLNADQQSRVSQWLVEYTQQRLSLAS

3D structure

PDB

2qcu Structure of glycerol-3-phosphate dehydrogenase, an essential monotopic membrane enzyme involved in respiration and metabolism.

Chain

Resolution

1.75 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.1.5.3: glycerol-3-phosphate dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PO4	A	R54 Y55 R317 R332	R52 Y53 R315 R330
BS02	FAD	A	I9 G10 G12 I13 N14 E33 A34 C39 A40 T41 S42 A44 S45 S46 L48 H50 A172 T206 G207 W209 G231 R317 G353 K354 L355 T356	I7 G8 G10 I11 N12 E31 A32 C37 A38 T39 S40 A42 S43 S44 L46 H48 A170 T204 G205 W207 G229 R315 G351 K352 L353 T354

Gene Ontology

	Molecular Function
GO:0004368	glycerol-3-phosphate dehydrogenase (quinone) activity
GO:0005515	protein binding
GO:0009055	electron transfer activity
GO:0016491	oxidoreductase activity
GO:0042803	protein homodimerization activity
GO:0071949	FAD binding

	Biological Process
GO:0006071	glycerol metabolic process
GO:0006072	glycerol-3-phosphate metabolic process
GO:0006796	phosphate-containing compound metabolic process
GO:0009060	aerobic respiration
GO:0009061	anaerobic respiration
GO:0019563	glycerol catabolic process
GO:0019637	organophosphate metabolic process
GO:0046168	glycerol-3-phosphate catabolic process

	Cellular Component
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009331	glycerol-3-phosphate dehydrogenase (FAD) complex

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Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:2qcu, PDBe:2qcu, PDBj:2qcu
PDBsum	2qcu
PubMed	18296637
UniProt	P13035\|GLPD_ECOLI Aerobic glycerol-3-phosphate dehydrogenase (Gene Name=glpD)

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