Structure of PDB 2qb4 Chain A

Receptor sequence

>2qb4A (length=510) Species: 224324 (Aquifex aeolicus VF5) [Search protein sequence]

REHWATRLGLILAMAGNAVGLGNFLRFPVQAAENGGGAFMIPYIIAFLLV
GIPLMWIEWAMGRYGGAQGHGTTPAIFYLLWRNRFAKILGVFGLWIPLVV
AIYYVYIESWTLGFAIKFLVGLVPEPPPTDPDSILRPFKEFLYSYIGVPK
GDEPILKPSLFAYIVFLITMFINVSILIRGISKGIERFAKIAMPTLFILA
VFLVIRVFLLETPNGTAADGLNFLWTPDFEKLKDPGVWIAAVGQIFFTLS
LGFGAIITYASYVRKDQDIVLSGLTAATLNEKAEVILGGSISIPAAVAFF
GVANAVAIAKAGAFNLGFITLPAIFSQTAGGTFLGFLWFFLLFFAGLTSS
IAIMQPMIAFLEDELKLSRKHAVLWTAAIVFFSAHLVMFLNKSLDEMDFW
AGTIGVVFFGLTELIIFFWIFGADKAWEEINRGGIIKVPRIYYYVMRYIT
PAFLAVLLVVWAREYIPKIMEETHWTVWITRFYIIGLFLFLTFLVFLAER
RRNHESAGTL

3D structure

PDB

2qb4 Antidepressant binding site in a bacterial homologue of neurotransmitter transporters.

Chain

Resolution

1.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	NA	A	G20 V23 G24 A351 T354 S355	G16 V19 G20 A345 T348 S349
BS02	NA	A	A22 V23 N27 T254 N286	A18 V19 N23 T248 N280
BS03	LEU	A	A22 G24 L25 G26 Y108 F253 T254 S256 F259	A18 G20 L21 G22 Y104 F247 T248 S250 F253
BS04	DSM	A	R30 V33 Q34 I111 A319 F320 D401	R26 V29 Q30 I107 A313 F314 D395
BS05	DSM	A	R193 F194 I197 F350	R187 F188 I191 F344

Gene Ontology

	Biological Process
GO:0035725	sodium ion transmembrane transport

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:2qb4, PDBe:2qb4, PDBj:2qb4
PDBsum	2qb4
PubMed	17687333
UniProt	O67854

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