Structure of PDB 2qaf Chain A

Receptor sequence
>2qafA (length=329) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
GLVPRGSMGFKVKLEKRRNAINTCLCIGLDPDEKDIENFMKNEKENNYNN
IKKNLKEKYINNVSIKKDILLKAPDNIIREEKSEEFFYFFNHFCFYIINE
TNKYALTFKMNFAFYIPYGSVGIDVLKNVFDYLYELNIPTILDMKINDIG
NTVKNYRKFIFEYLKSDSCTVNIYMGTNMLKDICYDEEKNKYYSAFVLVK
TTNPDSAIFQKNLSLDNKQAYVIMAQEALNMSSYLNLEQNNEFIGFVVGA
NSYDEMNYIRTYFPNCYILSPGIGAQNGDLHKTLTNGYHKSYEKILINIG
RAITKNPYPQKAAQMYYDQINAILKQNME
3D structure
PDB2qaf Structure-activity relationships of C6-uridine derivatives targeting plasmodia orotidine monophosphate decarboxylase
ChainA
Resolution1.95 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 4.1.1.23: orotidine-5'-phosphate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U5P A D23 K102 N104 K138 T194 T195 P264 Q269 G293 R294 D30 K109 N111 K145 T201 T202 P271 Q276 G300 R301
BS02 U5P A D141 I142 T145 D148 I149 T152
Gene Ontology
Molecular Function
GO:0004590 orotidine-5'-phosphate decarboxylase activity
GO:0005515 protein binding
GO:0016831 carboxy-lyase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0044205 'de novo' UMP biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2qaf, PDBe:2qaf, PDBj:2qaf
PDBsum2qaf
PubMed18189347
UniProtQ8IJH3

[Back to BioLiP]